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completed research


  • Deribe K, Brooker SJ, Pullan RL, Sime H, Gebretsadik A, Assefa A, Kebede A, Hailu A, Rebollo MP, Shafi O, Bockarie MJ, Aseffa A, Reithinger R, Cano J, Enquselassie F, Newport MJ, Davey G., 2015. Epidemiology and individual, household and geographical risk factors of podoconiosis in Ethiopia: results from the first nationwide mapping. Am J Trop Med Hyg. 92(1), 148-158.
  • Sime H, Deribe K, Assefa A, Newport J M, Enquselassie F, Gebretsadik A, Kebede A, Hailu A, Shafi O, Aseffa A, Reithinger R, Brooker J S, Pullan L Rl, Cano J, Meribo K, Pavluck A, Bockarie J M, Rebollo P M, Davey G., 2014. Integrated mapping of lymphatic filariasis and podoconiosis: lessons learnt from Ethiopia.  Parasites & Vectors, 7:397.
  • Deribe K, Brooker SJ, Pullan RL, Hailu A, Enqusellassie  F, Reithinger R, Newport MJ, Davey G., 2013. Spatial distribution of podoconiosis in Ethiopia in relation to environmental factors: a historical reviewPLoS ONE;  8(7):e68330.
  • Tekola Ayele F, Alemu G, Davey G, Ahrens C., 2013. Community-based survey of podoconiosis in Bedele Zuria woreda, West Ethiopia. Int Health, 5:119-125.
  • Molla YB, Tomczyk S, Amberbir T, Tamiru A, Davey G., 2012. Podoconiosis in East and West Gojam Zones, northern EthiopiaPLoS NTD; 6(7):e1744.
  • Alemu G, Tekola F, Daniel T, Ahrens C, Davey G, 2011. Burden of Podoconiosis in Poor Rural Communities in Gulliso woreda, West Ethiopia. PLoS NTD 2011; 5(6):e1184.
  • Birrie, H., Balcha, F., Jemaneh, L., 1997. Elephantiasis in Pawe settlement area: podoconiosis or bancroftian filariasis? Ethiop. Med. J. 35, 245-250.
  • Cohen, L.B., 1960. Idiopathic lymphoedema of Ethiopia and Kenya. East. Afr. Med. J. 37, 53-74.
  • Corachan, M., Tura, J.M., Campo, E., Soley, M., Traveria, A., 1988. Podoconiosis in Aequatorial Guinea.  Report of two cases from different geological environments. Trop. Geog. Med. 40, 359-364.
  • Crivelli, P., 1986. Non-filarial elephantiasis in Nyambene range: a geochemical disease. East. Afr. Med. J. 63, 191-194.
  • de Lalla, F., Zanoni, P., Lunetta, Q., Moltrasio, G.,1988. Endemic non-filarial elephantiasis in Iringa District, Tanzania: a study of 30 patients. Trans. R. Soc. Trop. Med. Hyg. 82, 895-897.
  • Desta, K., Ashine, M., Davey, G., 2003. Prevalence of podoconiosis (endemic non-filarial elephantiasis) in Wolaitta, Southern Ethiopia. Trop. Doct. 32, 217-220.
  • Geshere Oli, G., Tekola Ayele, F., Petros, B., 2012. Parasitological, serological and clinical evidence of high prevalence of podoconiosis (non-filarial elephantiasis) in Midekegn district, central Ethiopia. Trop. Med. Int. Health. DOI:10.1111/j.1365-3165.2012.02978
  • Kloos, H., Bedri Kello, A., Addus, A., 1992. Podoconiosis (endemic non-filarial elephantiasis) in two resettlement schemes in western Ethiopia. Trop. Doct. 22, 109-112.
  • Mengistu, G., Humber, D.P., Ersumo, M., Mamo, T., 1987. High prevalence of elephantiasis in Ocholo, south-west Ethiopia.  Ethiop. Med. J. 25, 203-207.
  • Morrone A, Padovese V, Dassoni F, Pajno MC, Marrone R, et al, 2011. Podoconiosis: an experience from Tigray, Northern Ethiopia. J. Am. Acad. Dermatol. 65, 214-5.
  • Onapa, A.W., Simonsen, P.E., Pedersen, E.M., 2001. Non-filarial elephantiasis in the Mt Elgon area (Kapchorwa District) of Uganda. Acta. Trop. 78, 171-176.
  • Oomen, A.P., 1969. Studies on elephantiasis of the legs in Ethiopia. Trop. Geog. Med. 21, 236-253.
  • Price, E.W., 1973. Non-filarial elephantiasis of the lower legs in Ethiopia. Trop.Geog. Med. 25, 23-27.
  • Price, E.W., 1974a. Endemic elephantiasis of the lower legs in Ethiopia, an epidemiological survey. Ethiop. Med. J. 12, 77-90.
  • Price, E.W., 1974b. The relationship between endemic elephantiasis of the lower legs and the local soils and climate. A study in Wollamo District, Southern Ethiopia. Trop. Geog. Med. 26, 225-230.
  • Price, E.W., 1976. Endemic elephantiasis of the lower legs in Rwanda and Burundi. Trop. Geog. Med 28, 283-290.
  • Price, E.W.., Henderson, W.J., 1981. Endemic elephantiasis of the lower legs in the United Cameroon Republic. Trop. Geog. Med. 33, 23-29.
  • Price, E.W., McHardy, W.J., Pooley, F.D., 1981. Endemic elephantiasis of the lower legs as a health hazard of barefooted agriculturalists in Cameroon, West Africa. Ann. Occ. Hyg. 24,1-8.
  • Ruberanziza E, Mupfasoni D, Karibushi B, Rujeni N, Kabanda G, Kabera M, et al, 2009. Mapping of Lymphatic Filariasis in Rwanda. J. Lymphoedema. 4(1):20-3. 
  • Ruiz, L., Campo, E., Corachan, M., 1994. Elephantiasis in Sao Tome and Principe. Acta. Trop. 57, 29-34.
  • Tada, M.S., Marsden, P.D., 1993. Probable podoconiosis in Brasilia. Rev Soc Bras. Med. Trop. 26, 255.
  • Wanji S, Tendongfor N, Esum M, Che JN, Mand S, Tanga Mbi C et al, 2008. Elephantiasis of non-filarial origin (podoconiosis) in the highlands of north-western Cameroon. Ann. Trop. Med. Parasitol. 102(6):1-12.

Economic, Social and Ethical Consequences

Diagnosis and Clinical Staging

  • Desta K, Ashine M, Davey G, 2007. Predictive value of clinical assessment of patients with podoconiosis in an endemic community setting. Trans. Roy. Soc. Trop. Med. Hyg. 101,621-623.
  • Price, E.W., 1983. Endemic elephantiasis: early signs and symptoms, and control. Eth. Med J. 21, 243-253.
  • Price, E.W., 1984. Pre-elephantiasic stage of endemic non-filarial elephantiasis: podoconiosis. Trop. Doc. 14,115-119.
  • Tekola F, Ayele Z, HaileMariam D, Fuller C, Davey G, 2008.Development and testing of a de novo staging system for podoconiosis. Trop. Med. Int. Health. 13,1277-83.

Aetiology and Pathogenesis

  • Le Blond JS, Cuadros J, Molla YB, Berhanu T, Umer M, Baxter PJ, Davey G. Weathering of the Ethiopian volcanic province: A new weathering index to characterize and compare soils. Am Mineral (preprint).
  • Molla YB, Wardrop NA, Le Blond JS, Baxter P, Newport MJ, Atkinson PM, Davey G., 2014. Modelling environmental factors correlated with podoconiosis.  Int J Health Geog, 13, 24.
  • Tekola-Ayele F, Adeyemo A, Hailu E, Aseffa A, Davey G, Rotimi CN, Newport MJ., 2014. Novel genomic signals of recent selection in an Ethiopian population. Eur J Hum Gen, doi:10.1038/ejhg.2014.233.
  • Tomczyk S, Deribe K, Brooker SJ, Clark H, Rafique K, Knopp S, Utzinger J, Davey G., 2014. Association between Footwear Use and Neglected Tropical Diseases: A Systematic Review and Meta-Analysis. PLoS NTD, 8(11): e3285.
  • Belayneh Y, Le Blond J, Wardrop N, Baxter P, Atkinson P, Newport M, Davey G., 2013. Individual correlates of podoconiosis in areas of varying endemicity. PLoS NTD, 7(12): e2554.
  • Fergusson JS, Yeshanehe W, Matts PJ, Davey G, Mortimer PS, Fuller LC., 2013. Assessment of Skin Barrier Function in Podoconiosis: Measurement of Stratum Corneum Hydration and Trans Epidermal Water Loss.  Br J Derm., 168, 550-554.
  • Addisu S, El-Metwally TH, Davey G, Worku Y, Titheradge M, 2010. The role of transforming growth factor β1 and oxidative stress in podoconiosis pathogenesis. Br. J. Derm., 162, 998-1003.
  •  Blanke JH, Price EW, Rendell HM, Terry J, Townsend PD, Wintle AG, 1983. Correlations between elephantiasis and thermoluminescence of volcanic soils. Rad. Effects., 73, 103-113.
  • Davey G, GebreHanna E, Adeyemo A, Rotimi C, Newport M, Desta K, 2007. Podoconiosis: a tropical model of gene-environment interaction? Trans. Roy. Soc. Trop. Med. Hyg., 101, 91-96.
  • Fyfe NCM, Price EW, 1985. The effects of silica on lymph nodes and vessels – a possible mechanism in the pathogenesis of non-filarial endemic elephantiasis. Trans. Roy. Soc. Trop. Med. Hyg., 79, 645-651.
  • Morrison C, Davey G, 2009. Assessment of respiratory function in patients with podoconiosis. Trans. Roy. Soc. Trop. Med. Hyg., 103, 315-317.
  • Price EW, 1972. A possible genetic factor in non-filarial elephantiasis of the lower legs. Eth. Med. J., 10, 87-93.
  • Price EW, 1974. The relationship between endemic elephantiasis of the lower legs and the local soils and climate. Trop. Geog. Med. 26, 225-230.
  • Price EW, 1976. The association of endemic elephantiasis of the lower legs in East Africa with soil derived from volcanic rocks. Trans. Roy. Soc. Trop. Med. Hyg., 70, 288-295.
  • Price EW, 1977. The site of lymphatic blockade in endemic (non-filarial) elephantiasis of the lower legs. J. Trop. Med. Hyg., 70, 230-237.
  • Price EW, Bailey D, 1984. Environmental factors in the etiology of endemic elephantiasis of the lower legs in tropical Africa. Trop. Geog. Med., 36, 1-5.
  • Price EW, Henderson WJ. The elemental content of lymphatic tissues of barefoot people in Ethiopia, with reference to endemic elephantiasis of the lower legs. Trans. Roy. Soc. Trop. Med. Hyg., 72, 132-136.
  • Price EW, Plant DA, 1990. The significance of particle size of soils as a risk factor in the etiology of podoconiosis. Trans. Roy. Soc. Trop. Med. Hyg., 84, 885-886.
  • Tekola F, Adeyemo A, Finan C, Hailu E, Sinnott P, Diaz Burlinson N, Aseffa A, Rotimi CN, Newport MJ, Davey G, 2012. The HLA Class II Locus Confers Susceptibility to Podoconiosis (Non Filarial Elephantiasis). New Eng. J. Med., 366, 1200-1208.

Treatment and Care

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